Autoimmune hepatitis: Symptoms, diagnosis, and treatment

Although less prevalent than other forms of hepatitis, researchers are still uncertain how common autoimmune hepatitis is in the population. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) point out research from northern Europe that shows an estimated 10 to 24 out of every 100,000 people have autoimmune hepatitis.

The disease may be a lifelong one. However, most people can manage the symptoms, bring the condition into remission, and slow liver damage.


Symptoms of autoimmune hepatitis can vary.

This may be due to the severity of the initial liver damage is in each case, and people may experience many different symptoms, ranging from mild to severe. These may include:

  • loss of appetite
  • fatigue
  • nausea
  • jaundice with yellowing skin and whites of the eyes
  • abdominal pain

Anyone with these symptoms who does not have a diagnosis should see a doctor.

Sometimes a person with autoimmune hepatitis may show little or no symptoms until scar tissue from cirrhosis causes its own complications. Other symptoms may show up, as the disorder progresses, and more liver tissue becomes damaged.

These could include:

  • loss of weight
  • swollen legs, ankles, and feet
  • itchy skin
  • fluid in the abdomen

Not all symptoms will show up in everyone with the disorder. More symptoms may show up if the person has other issues in addition to autoimmune hepatitis, such as other autoimmune conditions.

Complications may also occur if there is too much damage to the liver or if the person leaves the condition for too long without receiving treatment. Complications can be serious and include:

  • cirrhosis or scar tissue on the liver
  • liver failure or end-stage liver disease
  • liver cancer

Complications may require extensive treatments, and a person may need a liver transplant in some cases.

The goal of treatment is to suppress symptoms and control the disease, as best as possible.

The first treatment many doctors provide is corticosteroids or immune system-suppressing drugs. These medications work to lower activity of the immune system in general, which may help slow the attack on the liver.

Treatment will also include regular blood tests to be sure the body is responding well to the treatment.

It is possible for autoimmune hepatitis to fail to respond to treatment, and doctors may recommend additional drugs to control inflammation or prevent liver damage. In these cases, people may be more at risk of complications that then require their own treatments.

How can diet improve the condition?

As the NIDDK note, there is no direct research to suggest diet or nutrition improve autoimmune hepatitis.

Doctors may, however, recommend changes in diet, as part of a general treatment plan. This may be especially important if damage to the liver leads to complications, such as cirrhosis.

Doctors will warn people to avoid alcohol in most cases, as autoimmune hepatitis can damage the liver.


The condition may go into remission with the correct treatment plan. Remission occurs when symptoms disappear, and test results show normal liver function.

Doctors will often carefully reduce any medications the person is taking during remission, and it is essential to perform liver function tests to check for enzyme levels and see if symptoms return.

Doctors may try several medications to achieve remission. If a person relapses, their doctor will restart or increase their medication to bring symptoms under control again and return to remission.


Autoimmune hepatitis often lasts a lifetime. People need to work closely with a doctor to monitor symptoms and control the condition. This also helps prevent any potentially serious complications. Many people find effective treatments that provide relief and help manage the condition.

Anyone who is uncertain about their treatment should talk to a doctor about the options. It is essential that people tell their doctor about all medications and supplements they use, as there may be interactions that cause unforeseen complications.

Regular checkups and adjustments in medication are crucial for successful treatment, and many people can find ways to control their symptoms and force the condition into remission.

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